SMALL INTERFERING RNA MEDIATED POLY (ADP-RIBOSE) POLYMERASE-1 INHIBITION UPREGULATES THE HEAT SHOCK RESPONSE IN A MURINE FIBROBLAST CELL LINE

Small interfering RNA mediated Poly (ADP-ribose) Polymerase-1 inhibition upregulates the heat shock response in a murine fibroblast cell line

Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) is a highly conserved multifunctional enzyme, and its catalytic activity is stimulated by DNA breaks.The activation of PARP-1 and subsequent depletion of nicotinamide adenine dinucleotide (NAD+) and adenosine Vitamin B-6 triphosphate (ATP) contributes to significant cytotoxicity in inflammation of va

read more